盐酸双芬麦兰
- CAS号:62232-46-6
- 英文名:Bifemelane HCl
- 中文名:盐酸双芬麦兰
- CBNumber:CB7947364
- 分子式:C18H23NO.ClH
- 分子量:305.847
- MOL File:62232-46-6.mol
- 熔点 :117-121°
- 溶解度 :Soluble to 100 mM in water and to 100 mM in DMSO
- 形态 :Powder
- 颜色 :White to yellow
- 毒性 :LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981)
盐酸双芬麦兰性质、用途与生产工艺
- 生物活性 Bifemelane hydrochloride (MCI-2016) 是一种有效，选择性和竞争性的单胺氧化酶 A (MAO-A) 抑制剂，Ki 值为 4.20 μM，它也非竞争性地抑制 MAO-B，Ki 为 46.0 μM。Bifemelane hydrochloride 具有很强的抗抑郁活性，可用于研究与脑血管疾病有关的认知和情绪障碍。
-
靶点
MAO-A
4.2 μM (Ki)
MAO-B
46 μM (Ki)
-
体外研究
Bifemelane inhibits MAO-A in a dose-dependent manner, with K i s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K i s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively. -
体内研究
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.Animal Model: Wistar male rats (230-270 g) are induced hypothermia by Reserpine Dosage: 20, 40, 80 mg/kg Administration: A single i.p. Result: Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
- 更新日期：2024/11/08
- 产品编号：HY-B1558A
- 产品名称：Bifemelane hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：285元
- 更新日期：2024/11/08
- 产品编号：HY-B1558A
- 产品名称：Bifemelane HCl Bifemelane hydrochloride
- CAS编号：62232-46-6
- 包装：5mg
- 价格：750元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
