SR 11302
- CAS号:160162-42-5
- 英文名:SR 11302
- 中文名:SR 11302
- CBNumber:CB7844692
- 分子式:C26H32O2
- 分子量:376.53
- MOL File:160162-42-5.mol
- 沸点 :541.6±30.0 °C(Predicted)
- 密度 :1.048±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :crystalline solid
- 酸度系数(pKa) :4.67±0.33(Predicted)
- 颜色 :Light yellow to yellow
SR 11302性质、用途与生产工艺
- 生物活性 SR 11302 是激活蛋白-1 (AP-1) 转录因子抑制剂。SR 11302 是一种类视黄醇，可特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。
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靶点
AP-1
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体外研究
SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα.
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells.
SR 11302 (SR-11302; 2 µM; 48 hours) inhibits Helicobacter pylori ( H. pylori )-induced cell proliferation in adenocarcinoma gastric (AGS) cells.
SR 11302 (2 µM; 24 hours) inhibits H. pylori -induced expression of β-catenin and c-myc in AGS cells. -
体内研究
SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr -/- mice in a dose-dependent manner.
Animal Model: Vldlr -/- mice Dosage: Low dose 0.5 mg/kg and high dose 1 mg/kg body weight Administration: Orally gavaged daily from P5 to P15 Result: High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.
- 更新日期：2024/11/08
- 产品编号：HY-15870
- 产品名称：SR 11302
- CAS编号：
- 包装：1 mg
- 价格：990元
- 更新日期：2024/11/08
- 产品编号：HY-15870
- 产品名称：SR 11302 SR 11302
- CAS编号：160162-42-5
- 包装：5mg
- 价格：3600元
- 公司名称：Novachemistry
- 联系电话：44-20819178-90 02081917890
- 电子邮件：info@novachemistry.com
- 国家：英国
- 产品数：4381
- 优势度：58
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
