SR 11302

生物活性靶点体外研究体内研究 SR 11302 试剂级价格

SR 11302

CAS号:160162-42-5
英文名:SR 11302
中文名:SR 11302
CBNumber:CB7844692
分子式:C26H32O2
分子量:376.53
MOL File:160162-42-5.mol

SR 11302化学性质

沸点 :541.6±30.0 °C(Predicted)
密度 :1.048±0.06 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :Soluble in DMSO
形态 :crystalline solid
酸度系数(pKa) :4.67±0.33(Predicted)
颜色 :Light yellow to yellow

SR 11302性质、用途与生产工艺

生物活性 SR 11302 是激活蛋白-1 (AP-1) 转录因子抑制剂。SR 11302 是一种类视黄醇，可特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。
靶点

AP-1
体外研究

SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα.
SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells.
SR 11302 (SR-11302; 2 µM; 48 hours) inhibits Helicobacter pylori ( H. pylori )-induced cell proliferation in adenocarcinoma gastric (AGS) cells.
SR 11302 (2 µM; 24 hours) inhibits H. pylori -induced expression of β-catenin and c-myc in AGS cells.

体内研究

SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr ^-/- mice in a dose-dependent manner.

Animal Model:	Vldlr ^-/- mice
Dosage:	Low dose 0.5 mg/kg and high dose 1 mg/kg body weight
Administration:	Orally gavaged daily from P5 to P15
Result:	High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.