ChemicalBook CAS数据库列表 Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-

Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-

CAS号:2416095-00-4
英文名:Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-
中文名:
CBNumber:CB78382185
分子式:C12H13Cl2NO6S2
分子量:402.27
MOL File:2416095-00-4.mol

Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-化学性质

Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-性质、用途与生产工艺

生物活性 CBR-470-2 是甘氨酸取代的类似物，可以激活 NRF2 信号传导。CBR-470-2 可用于调节糖酵解。
靶点

NRF2
体外研究

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts.

体内研究

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.

Animal Model:	Balb/C mice (5-week old) are exposed to UVB
Dosage:	50 mg/kg
Administration:	P.o. twice daily for 10 days
Result:	Resulted in comparable beneficial effects on erythema histological scores and total wounded area. Decreased epidermal thickness in response to UV exposure.

Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-上下游产品信息

上游原料

下游产品

Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-生产厂家