ChemicalBook CAS数据库列表 蝴蝶霉素
蝴蝶霉素
- CAS号:93908-02-2
- 英文名:REBECCAMYCIN
- 中文名:蝴蝶霉素
- CBNumber:CB7747508
- 分子式:C27H21Cl2N3O7
- 分子量:570.38
- MOL File:93908-02-2.mol
蝴蝶霉素化学性质
- 储存条件 :−20°C
- 溶解度 :DMSO: ≥3 mg/mL
- 形态 :solid
- 颜色 :yellow
安全信息
- WGK Germany :-
蝴蝶霉素性质、用途与生产工艺
- 生物活性 Rebeccamycin，一种抗肿瘤抗生素，抑制 DNA 拓扑异构酶 I (DNA topoisomerase I)。Rebeccamycin 通过毒害拓扑异构酶 I 发挥其主要的抗肿瘤作用，对蛋白激酶 C 和拓扑异构酶 Ⅱ 的作用较小。
-
靶点
Topoisomerase I
Traditional Cytotoxic Agents
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体外研究
Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis . -
体内研究
Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.
Animal Model: CDF1 mice (B16 melanoma, L1210 leukemia) Dosage: 2, 4, 8, 16, 32, 64, 128, 256 mg/kg Administration: I.p.; daily for 9 days Result: Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
蝴蝶霉素上下游产品信息
上游原料
下游产品
蝴蝶霉素生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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