ChemicalBook CAS数据库列表 CHPG
CHPG
- CAS号:170846-74-9
- 英文名:CHPG
- 中文名:CHPG
- CBNumber:CB7723281
- 分子式:C8H8ClNO3
- 分子量:201.61
- MOL File:170846-74-9.mol
CHPG化学性质
- 沸点 :407.3±45.0 °C(Predicted)
- 密度 :1.531±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: ≥10mg/mL
- 形态 :solid &_& white solid
- 酸度系数(pKa) :1.61±0.10(Predicted)
- 颜色 :white
安全信息
CHPG性质、用途与生产工艺
- 生物活性 CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
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靶点
mGlu 5
NF-κB
ERK
Akt
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体外研究
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO 2 -induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
Cell Line: BV2 microglial cells Concentration: 10, 50, 100 and 500 µM Incubation Time: 24 hours Result: Increased the cell viability. Apoptosis Analysis
Cell Line: BV2 microglial cells Concentration: 0.5 mM Incubation Time: 30 mins Result: Protected BV2 cells against SO 2 -induced apoptosis. Western Blot Analysis
Cell Line: BV2 microglial cells Concentration: 0.5 mM Incubation Time: 30 mins Result: Increased the expression of TSG-6 in both mRNA and protein levels. -
体内研究
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g Dosage: 250 nM Administration: Injection; for 7 days Result: Reduced significantly cerebral lesion volume.
CHPG上下游产品信息
上游原料
下游产品
CHPG 试剂级价格
- 更新日期：2024/04/30
- 产品编号：HY-101364
- 产品名称：CHPG
- CAS编号：
- 包装：1 mg
- 价格：1636元
- 更新日期：2024/04/30
- 产品编号：HY-101364
- 产品名称：CHPG CHPG
- CAS编号：170846-74-9
- 包装：5mg
- 价格：3600元
CHPG生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6913
- 优势度：91
