CHPG

生物活性靶点体外研究体内研究 CHPG 试剂级价格

CHPG

CAS号:170846-74-9
英文名:CHPG
中文名:CHPG
CBNumber:CB7723281
分子式:C8H8ClNO3
分子量:201.61
MOL File:170846-74-9.mol

CHPG化学性质

沸点 :407.3±45.0 °C(Predicted)
密度 :1.531±0.06 g/cm3(Predicted)
储存条件 :2-8°C
溶解度 :DMSO: ≥10mg/mL
形态 :solid &_& white solid
酸度系数(pKa) :1.61±0.10(Predicted)
颜色 :white

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :26
WGK Germany :3

CHPG性质、用途与生产工艺

生物活性 CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
靶点

mGlu ₅

NF-κB

ERK

Akt

体外研究

CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO ₂ derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO ₂ -induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.

Cell Viability Assay

Cell Line:	BV2 microglial cells
Concentration:	10, 50, 100 and 500 µM
Incubation Time:	24 hours
Result:	Increased the cell viability.

Apoptosis Analysis

Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Protected BV2 cells against SO ₂ -induced apoptosis.

Western Blot Analysis

Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Increased the expression of TSG-6 in both mRNA and protein levels.

体内研究

CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.

Animal Model:	Adult Sprague-Dawley male rats weighing 280-320 g
Dosage:	250 nM
Administration:	Injection; for 7 days
Result:	Reduced significantly cerebral lesion volume.