醋酸胸腺α1
- CAS号:62304-98-7
- 英文名:Thymosin α1
- 中文名:醋酸胸腺α1
- CBNumber:CB7678989
- 分子式:C129H215N33O55
- 分子量:3108.32
- MOL File:62304-98-7.mol
- 沸点 :2899.7±65.0 °C(Predicted)
- 密度 :1.360±0.06 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
- 形态 :A crystalline solid
- 颜色 :Sterile Filtered White lyophilized (freeze-dried) powder.
- 序列 :Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
- 稳定性 :Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles. - InChIKey :NZVYCXVTEHPMHE-WTRFZTBJNA-N
- WGK Germany :3
醋酸胸腺α1性质、用途与生产工艺
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概述
胸腺肽 alpha 1 (Thymosinα1)是一种治疗慢性乙型肝炎和增强免疫系统反应性的药物肽。
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存在
胸腺肽α1是一个高度保守酸多肽结构，主要分布在胸腺组织，尤其是胸腺上皮细胞中，另外，也存在于淋巴组织(如脾、淋巴结)和非淋巴组织(如肺、肾和脑)中，其分泌和释放并不受其他激素或者释放因子所调节。
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有关研究
体内试验显示，胸腺肽 alpha 1可以提高经刀豆蛋白A激活后小鼠淋巴细胞白介素2受体的表达水平，同时提高白介素2的分泌水平。
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应用
胸腺肽alpha 1是一个免疫调节化合物，能够提高Thl的免疫应答。胸腺肽α1对免疫缺陷的患者具有免疫调节作用，从而使胸腺肽α1被广泛应用到临床中。
- 生物活性 Thymalfasin (thymosin-alpha 1) 是一个免疫调节化合物，能够提高 Thl 的免疫应答。
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体外研究
Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects.
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体内研究
Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects.
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参考质量标准
外观?白色粉末纯度(HPLC) ≥98.0%
单杂≤1.0%
醋酸根含量5.0%～12.0%
水分含量≤10.0%
肽含量≥80.0%
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