富马酸单甲酯
- CAS号:2756-87-8
- 英文名:Monomethyl fumarate
- 中文名:富马酸单甲酯
- CBNumber:CB7505423
- 分子式:C5H6O4
- 分子量:130.1
- MOL File:2756-87-8.mol
- 熔点 :144-145 °C (lit.)
- 沸点 :250.0±23.0 °C(Predicted)
- 密度 :1.37 g/cm3
- 储存条件 :2-8°C
- 溶解度 :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :3.40±0.10(Predicted)
- 形态 :Solid
- 颜色 :Off-White
- 最大波长(λmax) :209nm(MeOH)(lit.)
- CAS 数据库 :2756-87-8(CAS DataBase Reference)
富马酸单甲酯性质、用途与生产工艺
- 生物活性 Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate) 是牛皮癣药物Fumaderm的活性代谢产物，是一种有效的 GPR109A 的激动剂。Monomethyl Fumarate 可预防与神经退行性疾病相关的主要功能障碍：氧化应激、线粒体功能障碍、凋亡和自噬。
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靶点
Target Value GPR109A
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体外研究
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC 50 of 70 nM. Monomethyl fumarate induces a dose-dependent Ca 2+ signal in GPR109A transfected cells with an EC 50 of 9.4 μM.
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
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体内研究
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
Animal Model: Albino BALB/c mice (male, 6 weeks old) Dosage: 50, 65, 75, 100 mg/kg Administration: IP Result: Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. - 用途 用作饲料防霉剂
- 更新日期：2024/11/11
- 产品编号：XW275687803
- 产品名称：富马酸单甲酯
- CAS编号：2756-87-8
- 包装：25G
- 价格：33元
- 更新日期：2024/11/11
- 产品编号：XW275687802
- 产品名称：富马酸单甲酯
- CAS编号：2756-87-8
- 包装：5G
- 价格：32元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
