(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- CAS号:150145-89-4
- 英文名:(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- 中文名:(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
- CBNumber:CB7485802
- 分子式:C10H11NO4
- 分子量:209.2
- MOL File:150145-89-4.mol
- 沸点 :425.3±40.0 °C(Predicted)
- 密度 :1.390±0.06 g/cm3(Predicted)
- 储存条件 :Store at RT
- 溶解度 :0.1 M NaOH: 15 mg/mL
- 形态 :solid
- 酸度系数(pKa) :1.76±0.10(Predicted)
- 颜色 :White to off-white
- 旋光性 (optical activity) :[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)
- 安全说明 :24/25
- WGK Germany :3
- 海关编码 :29224985
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE性质、用途与生产工艺
- 生物活性 (S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。
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靶点
mGluR
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体外研究
(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.
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体内研究
MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.
Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze Dosage: 20 μg Administration: Intraventricular injection; 20 μg; 4 days Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
- 更新日期：2024/11/08
- 产品编号：HY-100406
- 产品名称：(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG
- CAS编号：150145-89-4
- 包装：5mg
- 价格：800元
- 更新日期：2024/11/08
- 产品编号：HY-100406
- 产品名称：(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG
- CAS编号：150145-89-4
- 包装：10mg
- 价格：1100元
- 公司名称：SIGMA
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- 电子邮件：
- 国家：瑞士
- 产品数：6896
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- 公司名称：AXXORA, LLC
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- 电子邮件：alexis-ch@alexis-corp.com
- 国家：瑞士
- 产品数：1104
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- 公司名称：ALEXIS
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- 电子邮件：alexis-ch@alexis-corp.ch
- 国家：瑞士
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