生物活性 靶点 体外研究 体内研究 (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 试剂级价格
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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE

生物活性 靶点 体外研究 体内研究 (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 试剂级价格
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE,150145-89-4,结构式
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
  • CAS号:150145-89-4
  • 英文名:(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
  • 中文名:(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
  • CBNumber:CB7485802
  • 分子式:C10H11NO4
  • 分子量:209.2
  • MOL File:150145-89-4.mol
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE化学性质
  • 沸点 :425.3±40.0 °C(Predicted)
  • 密度 :1.390±0.06 g/cm3(Predicted)
  • 储存条件 :Store at RT
  • 溶解度 :0.1 M NaOH: 15 mg/mL
  • 形态 :solid
  • 酸度系数(pKa) :1.76±0.10(Predicted)
  • 颜色 :White to off-white
  • 旋光性 (optical activity) :[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)
安全信息
  • 安全说明 :24/25
  • WGK Germany :3
  • 海关编码 :29224985

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE性质、用途与生产工艺

  • 生物活性 (S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。
  • 靶点

    mGluR

  • 体外研究

    (S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.

  • 体内研究

    MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.

    Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze
    Dosage: 20 μg
    Administration: Intraventricular injection; 20 μg; 4 days
    Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE上下游产品信息
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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-100406
  • 产品名称：(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG
  • CAS编号：150145-89-4
  • 包装：5mg
  • 价格：800元
  • 更新日期：2024/11/08
  • 产品编号：HY-100406
  • 产品名称：(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (S)-MCPG
  • CAS编号：150145-89-4
  • 包装：10mg
  • 价格：1100元
(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE生产厂家
  • 公司名称：北京百灵威科技有限公司
  • 联系电话：010-82848833 400-666-7788
  • 电子邮件：jkinfo@jkchemical.com
  • 国家：中国
  • 产品数：94657
  • 优势度：76
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