5-胆甾烯-3Β,25-二醇

5-胆甾烯-3Β,25-二醇化学性质

熔点 :177-179 °C
沸点 :513.1±23.0 °C(Predicted)
密度 :1.03±0.1 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :chloroform: 50 mg/mL, clear, colorless to slightly yellow
形态 :solid
酸度系数(pKa) :15.03±0.70(Predicted)
颜色 :White or pale yellow
Merck :13,4846
BRN :3161259
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :INBGSXNNRGWLJU-ZHHJOTBYSA-N
SMILES :[C@@]12([H])CC[C@H]([C@H](C)CCCC(O)(C)C)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)CC3=CC[C@@]21[H] |&1:0,4,5,14,18,20,24,30,r|

安全信息

5-胆甾烯-3Β,25-二醇性质、用途与生产工艺

生物活性 25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA，EC50 约为 65 nM。
靶点

Human Endogenous Metabolite
体外研究

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems.

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