红陪酚
- CAS号:569-77-7
- 英文名:PURPUROGALLIN
- 中文名:红陪酚
- CBNumber:CB7329636
- 分子式:C11H8O5
- 分子量:220.18
- MOL File:569-77-7.mol
- 熔点 :275 °C (dec.)(lit.)
- 沸点 :321.11°C (rough estimate)
- 密度 :1.3824 (rough estimate)
- 折射率 :1.5140 (estimate)
- 储存条件 :−20°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :6.75±0.20(Predicted)
- 颜色 :Very Dark Brown
- Merck :7946
- 稳定性 :Air Sensitive
- LogP :2.050 (est)
红陪酚性质、用途与生产工艺
- 生物活性 Purpurogallin 是从栎属植物中提取的天然酚，具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性，其 IC50 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。
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靶点
IC50: 0.2 µM (xanthine oxidase)
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体外研究
Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.RT-PCR
Cell Line: BV2 murine microglial cells Concentration: 50 or 100 µM Incubation Time: 7 or 25 hours Result: Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression. Western Blot Analysis
Cell Line: BV2 murine microglial cells Concentration: 100 µM Incubation Time: 75 minutes, 90 minutes, 120 minutes Result: Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways. -
体内研究
Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.
Animal Model: Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH) Dosage: 100 μg/kg, 200 μg/kg, 400 μg/kg Administration: Intraperitoneal injection; for 48 or 72 hours Result: Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.
- 更新日期：2024/11/08
- 产品编号：HY-12136
- 产品名称：Purpurogallin
- CAS编号：
- 包装：1 mg
- 价格：228元
- 更新日期：2024/11/08
- 产品编号：HY-12136
- 产品名称：红陪酚 Purpurogallin
- CAS编号：569-77-7
- 包装：5mg
- 价格：500元
- 公司名称：Leancare Ltd.
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- 国家：英国
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