生物活性 靶点 体外研究 体内研究 BVT 2733 试剂级价格
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BVT 2733

生物活性 靶点 体外研究 体内研究 BVT 2733 试剂级价格
BVT 2733,376640-41-4,结构式
BVT 2733
  • CAS号:376640-41-4
  • 英文名:BVT 2733
  • 中文名:BVT 2733
  • CBNumber:CB72667358
  • 分子式:C17H21ClN4O3S2
  • 分子量:428.96
  • MOL File:376640-41-4.mol
BVT 2733化学性质
  • 沸点 :636.9±65.0 °C(Predicted)
  • 密度 :1.427±0.06 g/cm3(Predicted)
  • 储存条件 :2-8°C
  • 溶解度 :≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
  • 形态 :solid
  • 酸度系数(pKa) :6.36±0.10(Predicted)
  • 颜色 :Off-white to pink
安全信息
  • 海关编码 :2935909099

BVT 2733性质、用途与生产工艺

  • 生物活性 BVT 2733 是一种新型的、小分子、非甾体类、异构体选择性的 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) 的抑制剂。
  • 靶点
    TargetValue
    11β-HSD1
    ()
  • 体外研究

    BVT 2733 (100 μM; 24 hours) co-treatment with PA (100 µM) reduces MCP-1 expression in fully differentiation adipocytes.BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa.

    RT-PCR

    Cell Line: Differentiation adipocytes
    Concentration: 100 μM
    Incubation Time: 24 hours
    Result: Down-regulated MCP-1 mRNA level.
  • 体内研究

    BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice.BVT 2733 (oral administration; 100 mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo.

    Animal Model: Collagen-induced arthritis (CIA) mice
    Dosage: 100 mg/kg
    Administration: Oral administration; twice daily; 2 weeks
    Result: Reduced synovial inflammation and joint destruction.
    Animal Model: C57BL/6J mice
    Dosage: 100 mg/kg
    Administration: Oral administration; dosed (09.00 and 17.00 h); last 4 weeks
    Result: Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice.
BVT 2733上下游产品信息
上游原料
下游产品
BVT 2733 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：S0209
  • 产品名称：BVT 2733 BVT 2733
  • CAS编号：376640-41-4
  • 包装：5mg
  • 价格：657.46元
  • 更新日期：2024/11/08
  • 产品编号：S0209
  • 产品名称：BVT 2733 BVT 2733
  • CAS编号：376640-41-4
  • 包装：25mg
  • 价格：2383.47元
BVT 2733生产厂家
  • 公司名称：上海思言生物科技有限公司
  • 联系电话：021-50908862，442785678，326799392 18721037013
  • 电子邮件：siyansales@126.com
  • 国家：中国
  • 产品数：9627
  • 优势度：58
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