BMS-5

CAS号:1338247-35-0
英文名:N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
中文名:BMS-5
CBNumber:CB72598623
分子式:C17H14Cl2F2N4OS
分子量:431.29
MOL File:1338247-35-0.mol

BMS-5化学性质

密度 :1.54±0.1 g/cm3(Predicted)
储存条件 :Sealed in dry,Store in freezer, under -20°C
溶解度 :DMSO:PBS (pH 7.2) (1:5):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);6.96(Max Conc. mM)
酸度系数(pKa) :9.51±0.50(Predicted)
形态 :White powder.
颜色 :White to off-white

BMS-5性质、用途与生产工艺

生物活性 BMS-5 (LIMKi 3) 是一种有效的 LIM kinases (LIMK) 的抑制剂，对LIMK1和LIMK2的IC50值分别为7 nM和8 nM。
靶点
Target Value
LIMK1
(Cell-free assay) 7 nM
LIMK2
(Cell-free assay) 8 nM
体外研究

BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2 ^ΔEx2 mouse Schwann cells (MSCs) with an IC ₅₀ of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2 ^ΔEx2 MSC viability in a dose-dependent manner with an IC ₅₀ of 3.9 µM, but does not significantly reduce the viability of control Nf2 ^flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2 ^ΔEx2 MSC viability is 40% compared to 83% for controls.
体内研究

BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).

BMS-5上下游产品信息

上游原料

下游产品

BMS-5 试剂级价格

BMS-5生产厂家