ChemicalBook CAS数据库列表 1160514-60-2
1160514-60-2
- CAS号:1160514-60-2
- 英文名:1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
- 中文名:1160514-60-2
- CBNumber:CB72518795
- 分子式:C16H11Cl3F3N3O3
- 分子量:456.63
- MOL File:1160514-60-2.mol
1160514-60-2化学性质
- 熔点 :151-153 °C(Solv: toluene (108-88-3))
- 沸点 :534.0±50.0 °C(Predicted)
- 密度 :1.54±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO (up to 40 mg/ml).
- 形态 :powder
- 酸度系数(pKa) :9.97±0.70(Predicted)
- 颜色 :white to beige
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
1160514-60-2性质、用途与生产工艺
- 生物活性 Pyr3 是 TRPC3 的选择性抑制剂，其对 TRPC3 介导的 Ca2+ 内流的 IC50 值为 700 nM。
-
靶点
IC50: 700 nM (TRPC3).
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体外研究
Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca 2+ influx in a dose-dependent manner with the IC 50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca 2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC 50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2).
1160514-60-2上下游产品信息
上游原料
下游产品
1160514-60-2 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-108465
- 产品名称：Pyr3
- CAS编号：
- 包装：1 mg
- 价格：320元
- 更新日期：2024/11/08
- 产品编号：HY-108465
- 产品名称：1160514-60-2 Pyr3
- CAS编号：1160514-60-2
- 包装：5mg
- 价格：800元
1160514-60-2生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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