Neoenactin M1
- CAS号:32886-15-0
- 英文名:Neoenactin M1
- 中文名:Neoenactin M1
- CBNumber:CB72327829
- 分子式:C19H36N2O5
- 分子量:372.5
- MOL File:32886-15-0.mol
- 沸点 :578.1±60.0 °C(Predicted)
- 密度 :1.094±0.06 g/cm3(Predicted)
- 酸度系数(pKa) :8.46±0.50(Predicted)
Neoenactin M1性质、用途与生产工艺
- 生物活性 Lipoxamycin 是一种抗真菌抗生素,也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂,IC50 为 21 nM。
-
靶点
Serine palmitoyltransferase
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体外研究
Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida . Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme. -
体内研究
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.
- 公司名称:TargetMol Chemicals Inc.
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