乌诺前列酮
- CAS号:120373-36-6
- 英文名:UNOPROSTONE
- 中文名:乌诺前列酮
- CBNumber:CB7220472
- 分子式:C22H38O5
- 分子量:382.53
- MOL File:120373-36-6.mol
- 沸点 :562.9±40.0 °C(Predicted)
- 密度 :1.069±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMF: 25 mg/ml; DMSO: 17 mg/ml; Ethanol: 12 mg/ml; PBS (7.2): 90 μg/ml
- 酸度系数(pKa) :4.76±0.10(Predicted)
乌诺前列酮性质、用途与生产工艺
- 生物活性 Unoprostone 是一种前列腺素 F2α 类似物 (PGAs)，可通过激活 BK 通道来减少氧化应激和光诱导的视网膜细胞死亡以及吞噬功能障碍。Unoprostone 可以降低眼内压，局部用于青光眼或高眼压症。
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体外研究
Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H 2 O 2 treatment) protects against H 2 O 2 -induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations.
Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation.
Unoprostone has prostaglandin F 2α receptors (FP) binding affinity with a K i of 3.86 μM.
Cell Viability Assay
Cell Line: H 2 O 2 -induced photoreceptor cell Concentration: 0.01, 0.1, 1 μM Incubation Time: 1 hour before H 2 O 2 treatment Result: Protected against H 2 O 2 -induced cell death in a concentration-dependent manner. -
体内研究
Unoprostone (0.06%, 0.12%; topical instillation; 3 µl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner.
Animal Model: Male mice (6 weeks old) Dosage: 0.06%, 0.12% Administration: Topical instillation; 3 µl Result: Reduced mouse IOP in a dose-dependent manner.
- 公司名称：Carbone Scientific CO., LTD
- 联系电话：--
- 电子邮件：sales@carbonesci.com
- 国家：英国
- 产品数：6666
- 优势度：30
