ChemicalBook CAS数据库列表 酒石酸长春氟宁
酒石酸长春氟宁
- CAS号:194468-36-5
- 英文名:Vinflunine Ditartrate
- 中文名:酒石酸长春氟宁
- CBNumber:CB71873477
- 分子式:C49H59F2N4O14
- 分子量:966.0079664
- MOL File:194468-36-5.mol
酒石酸长春氟宁化学性质
- 熔点 :244-246°C (dec)
- 储存条件 :-20°C Freezer
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :Solid
- 颜色 :White to Light Beige
酒石酸长春氟宁性质、用途与生产工艺
- 生物活性 Vinflunine ditartrate 是一种长春花生物碱家族的氟化微管抑制剂。Vinflunine ditartrate 具有抗血管生成,破坏血管和抗转移的活性。Vinflunine ditartrate 可用于尿路上皮移行细胞癌,非小细胞肺癌和乳腺癌的研究。
-
靶点
microtubule
-
体外研究
Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology.
Vinflunine (0.01-10 μM; 1 h) disrupts newly formed capillary-like structures.
Vinflunine (0.01-10 μM; 1 h) inhibits endothelial cell motility, with an IC 50 of 0.71 μM.
Vinflunine (0.001-10 μM; 1-72 h) inhibits endothelial cell proliferation in vitro.
-
体内研究
Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells.
Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner.Animal Model: Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells Dosage: 0.08, 0.16, 1.25, 5, 10, 20 mg/kg Administration: I.v. on days 4, 7, 11, 14, 18 and 21 after tumour cell implantation Result: Induced a dose-dependent reduction in the number of metastatic foci at the surface of the liver and was well tolerated.
酒石酸长春氟宁上下游产品信息
上游原料
下游产品
酒石酸长春氟宁 试剂级价格
- 更新日期:2023/03/20
- 产品编号:HY-B0628B
- 产品名称:Vinflunine ditartrate
- CAS编号:
- 包装:1 mg
- 价格:4000元
- 更新日期:2023/03/20
- 产品编号:HY-B0628B
- 产品名称:酒石酸长春氟宁 Vinflunine ditartrate
- CAS编号:194468-36-5
- 包装:5mg
- 价格:12000元
酒石酸长春氟宁生产厂家
- 公司名称:TORONTO
- 联系电话:--
- 电子邮件:info@trc-canada.com
- 国家:加拿大
- 产品数:6088
- 优势度:71
194468-36-5, 酒石酸长春氟宁相关搜索: