ChemicalBook CAS数据库列表 ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT

CAS号:151837-09-1
英文名:ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
中文名:ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
CBNumber:CB7155048
分子式:C16H27N6O5PS
分子量:446.46
MOL File:151837-09-1.mol

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT化学性质

安全信息

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT性质、用途与生产工艺

生物活性 Rp-cAMPS triethylammonium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。
靶点

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
体外研究

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
体内研究

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT上下游产品信息

上游原料

下游产品

更新日期：2024/11/08
产品编号：HY-100530
产品名称：ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT Rp-cAMPS triethylammonium salt
CAS编号：151837-09-1
包装：1mg
价格：6750元

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