ChemicalBook CAS数据库列表 (E)-3-(3H-咪唑-4-基)丙-2-烯酸
(E)-3-(3H-咪唑-4-基)丙-2-烯酸
- CAS号:7699-35-6
- 英文名:(E)-3-(3H-imidazol-4-yl)prop-2-enoic acid
- 中文名:(E)-3-(3H-咪唑-4-基)丙-2-烯酸
- CBNumber:CB71235758
- 分子式:C6H6N2O2
- 分子量:138.12
- MOL File:7699-35-6.mol
(E)-3-(3H-咪唑-4-基)丙-2-烯酸化学性质
- 熔点 :175-176 °C
- 沸点 :456.9±20.0 °C(Predicted)
- 密度 :1.430±0.06 g/cm3(Predicted)
- 储存条件 :-20°C
- 溶解度 :H2O: >10mg/mL
- 形态 :solid (fluffy)
- 酸度系数(pKa) :2.82±0.28(Predicted)
- 颜色 :white
- 水溶解性 :Soluble in water
- 敏感性 :Light Sensitive
安全信息
- 安全说明 :22-24/25
- WGK Germany :3
(E)-3-(3H-咪唑-4-基)丙-2-烯酸性质、用途与生产工艺
- 生物活性 cis-Urocanic acid 是一种 5-HT2A 受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合，Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。
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靶点
5-HT 2A Receptor
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体外研究
Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic.
Cell Viability Assay
Cell Line: Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs) Concentration: 10, 100, 1,000, and 5,000 μg/mL Incubation Time: 24, 48, or 72 hours Result: Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.
(E)-3-(3H-咪唑-4-基)丙-2-烯酸上下游产品信息
上游原料
下游产品
(E)-3-(3H-咪唑-4-基)丙-2-烯酸 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-113008A
- 产品名称：(E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid
- CAS编号：7699-35-6
- 包装：1 mg
- 价格：2133元
- 更新日期：2025/02/08
- 产品编号：HY-113008A
- 产品名称：(E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid
- CAS编号：7699-35-6
- 包装：5mg
- 价格：4200元
(E)-3-(3H-咪唑-4-基)丙-2-烯酸生产厂家
- 公司名称：APOLLO-NMR
- 联系电话：--
- 电子邮件：sales@apolloscientific.co.uk
- 国家：英国
- 产品数：6084
- 优势度：88
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