ChemicalBook CAS数据库列表 化合物 T15800
化合物 T15800
- CAS号:63676-25-5
- 英文名:Phenethipylone
- 中文名:化合物 T15800
- CBNumber:CB71179481
- 分子式:C27H25NO4S
- 分子量:459.56
- MOL File:63676-25-5.mol
化合物 T15800性质、用途与生产工艺
- 生物活性 LY117018,Raloxifene 类似物,是一种选择性雌激素受体 (estrogen receptor) 调节剂。LY117018 对乳腺癌细胞具有抗增殖作用。
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靶点
Estrogen receptor
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体外研究
LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation.
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC 50 of 1 μM.
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.Cell Proliferation Assay
Cell Line: MCF-7 cells Concentration: 1 μM Incubation Time: 96 hours Result: Inhibited MCF-7 cells proliferation with an IC 50 of 1 μM.
化合物 T15800上下游产品信息
上游原料
下游产品
化合物 T15800生产厂家
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6351
- 优势度:58