Lipoxamycin
- CAS号:11075-87-9
- 英文名:Lipoxamycin
- 中文名:Lipoxamycin
- CBNumber:CB71120397
- 分子式:C19H38N2O9S
- 分子量:470.58
- MOL File:11075-87-9.mol
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 40 mg/mL (94.89 mM; ultrasonic and warming and heat to 60°C)
- 形态 :Solid
- 颜色 :White to off-white
Lipoxamycin性质、用途与生产工艺
- 生物活性 Lipoxamycin hemisulfate 是一种抗真菌抗生素,也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂,IC50 为 21 nM。
-
靶点
Serine palmitoyltransferase
-
体外研究
Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida . Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme. -
体内研究
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.
- 更新日期:2024/04/30
- 产品编号:HY-119759A
- 产品名称:Lipoxamycin hemisulfate
- CAS编号:
- 包装:1 mg
- 价格:2682元
- 更新日期:2024/04/30
- 产品编号:HY-119759A
- 产品名称:Lipoxamycin Lipoxamycin hemisulfate
- CAS编号:11075-87-9
- 包装:5mg
- 价格:5900元
- 公司名称:CHEMICAL LAND21
- 联系电话:--
- 电子邮件:sales21@chemicalland21.com
- 国家:韩国
- 产品数:6315
- 优势度:74