ChemicalBook CAS数据库列表 氯瑞唑
氯瑞唑
- CAS号:117857-45-1
- 英文名:(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride
- 中文名:氯瑞唑
- CBNumber:CB71075257
- 分子式:C10H6Cl3N3
- 分子量:274.53
- MOL File:117857-45-1.mol
氯瑞唑化学性质
- 储存条件 :Inert atmosphere,2-8°C
- 溶解度 :<1.37mg/ml in DMSO; <1.37mg/ml in ethanol
- 形态 :Solid
- 颜色 :White to off-white
氯瑞唑性质、用途与生产工艺
- 生物活性 Loreclezole 是一种抗癫痫化合物,是选择性的 GABAA 受体 的调节剂,是 β2 或 β3 亚单位包含受体的正向变构调节剂。
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靶点
GABA A receptor.
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体内研究
Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.
Animal Model: Adult male Lister Hooded rats. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
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氯瑞唑 试剂级价格
- 更新日期:2024/11/08
- 产品编号:HY-105272
- 产品名称:Loreclezole
- CAS编号:
- 包装:1 mg
- 价格:430元
- 更新日期:2024/11/08
- 产品编号:HY-105272
- 产品名称:氯瑞唑 Loreclezole
- CAS编号:117857-45-1
- 包装:5mg
- 价格:950元
氯瑞唑生产厂家
- 公司名称:WAKO
- 联系电话:--
- 电子邮件:labchem-tec@wako-chem.co.jp
- 国家:日本
- 产品数:6819
- 优势度:80
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