SR 31747
- CAS号:132173-07-0
- 英文名:SR 31747
- 中文名:SR 31747
- CBNumber:CB71011640
- 分子式:
- 分子量:0
- MOL File:132173-07-0.mol
SR 31747性质、用途与生产工艺
- 生物活性 SR-31747 是一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 通过抑制固醇异构酶来阻止细胞增殖。
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靶点
Sigma ligand
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体外研究
SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.
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体内研究
In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED 50 , 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.
- 更新日期:2024/04/30
- 产品编号:HY-13751
- 产品名称:SR-31747
- CAS编号:
- 包装:1 mg
- 价格:1300元
- 更新日期:2024/04/30
- 产品编号:HY-13751
- 产品名称:SR 31747 SR-31747
- CAS编号:132173-07-0
- 包装:5mg
- 价格:2800元
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:Alchem Pharmtech,Inc.
- 联系电话:8485655694
- 电子邮件:sales@alchempharmtech.com
- 国家:美国
- 产品数:63711
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58
- 公司名称:APAC Pharmaceutical, LLC
- 联系电话:--
- 电子邮件:sales@apacpharma.com
- 国家:美国
- 产品数:6332
- 优势度:38