ZZW-115 hydrochloride
- CAS号:10122-45-9
- 英文名:ZZW-115 hydrochloride
- 中文名:ZZW-115 hydrochloride
- CBNumber:CB69041617
- 分子式:
- 分子量:0
- MOL File:Mol file
- 储存条件 :4°C, stored under nitroge
- 溶解度 :Ethanol: soluble
- 形态 :A solid
- 颜色 :Light brown to brown
- 水溶解性 :Water: 100 mg/mL (174.23 mM)
ZZW-115 hydrochloride性质、用途与生产工艺
- 生物活性 ZZW-115 hydrochloride 是一种有效的 NUPR1 抑制剂，Kd 为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。
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体外研究
ZZW-115 hydrochloride (0.1-33 μM; 72 hours) is efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).
ZZW-115 hydrochloride (0-100 μM; 24-72 hours) is efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
ZZW-115 hydrochloride induces pancreatic cell death by necrosis and apoptosis. ZZW-115 hydrochloride treatment induces a decrease in ATP production and induces a ROS overproduction.
LDH release is significantly higher in ZZW-115 hydrochloride-treated cells (MiaPaCa-2, 02-063, LIPC, Foie8b, and HN14 cells) than in control cells in a concentration-dependent manner. Similarly, caspase 3/7 activity is also greater in ZZW-115 hydrochloride-treated cells. These experiments demonstrated that ZZW-115 hydrochloride exerted both pronecrotic and proapoptotic effects.Cell Viability Assay
Cell Line: ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration: 0.1- 33 μM Incubation Time: 72 hours Result: Was efficient in killing cancer cells, with an IC 50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14). Cell Proliferation Assay
Cell Line: U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration: 0-100 μM Incubation Time: 24 or 72 hours Result: Was efficient to kill these tumor cells with an IC 50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells). -
体内研究
ZZW-115 hydrochloride (0.5-5 mg/kg; injection; daily for 30 days) inhibits the growth of pancreatic xenografted tumors.
ZZW-115 hydrochloride (5 mg/kg for 30 days; immunocompetent C57BL/6 mice were orthotopically implanted with Panc02 cells) treatment shows the tumor size is almost unmeasurable in some cases.Animal Model: NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells Dosage: 5, 2.5, 1.0, or 0.5 mg/kg Administration: Injection; daily for 30 days Result: When the mice were injected with 5 mg/kg ZZW-115 hydrochloride, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.
- 更新日期：2024/11/08
- 产品编号：HY-111838A
- 产品名称：ZZW-115 hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：1136元
- 更新日期：2024/11/08
- 产品编号：HY-111838A
- 产品名称：ZZW-115 hydrochloride ZZW-115 hydrochloride
- CAS编号：10122-45-9
- 包装：5mg
- 价格：2500元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38631
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- 公司名称：CAYMAN
- 联系电话：--
- 电子邮件：cayman@caymanchem.com
- 国家：美国
- 产品数：6213
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- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
