2-氨基-3-氯-1,4-萘醌

生物活性靶点体外研究 2-氨基-3-氯-1,4-萘醌试剂级价格

2-氨基-3-氯-1,4-萘醌

CAS号:2797-51-5
英文名:2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE
中文名:2-氨基-3-氯-1,4-萘醌
CBNumber:CB6741165
分子式:C10H6ClNO2
分子量:207.61
MOL File:2797-51-5.mol

2-氨基-3-氯-1,4-萘醌化学性质

熔点 :198-200 °C
沸点 :310℃
密度 :1.49
折射率 :1.5790 (estimate)
闪点 :141℃
储存条件 :Keep in dark place,Inert atmosphere,Room temperature
水溶解性 :Insoluble in water
溶解度 :DMSO: 250 mg/mL (1204.18 mM)
形态 :Powder
酸度系数(pKa) :0.70±0.20(Predicted)
颜色 :Orange
LogP :2.120
CAS 数据库 :2797-51-5(CAS DataBase Reference)
EPA化学物质信息 :2-Amino-3-chloro-1,4-naphthoquinone (2797-51-5)

安全信息

危险品标志 :T,N
危险类别码 :36/37/38-23-22-50/53-36
安全说明 :45-37/39-26-61-60
危险品运输编号 :UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany :3
RTECS号 :QL7350000
危险等级 :6.1
海关编码 :29223990
毒性 :LD50 oral in rat: 1360mg/kg

2-氨基-3-氯-1,4-萘醌性质、用途与生产工艺

生物活性 Quinoclamine 是一种萘醌衍生物，是一种 NF-κB 抑制剂。Quinoclamine 具有抗肿瘤活性。
靶点

NF-κB

体外研究

Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC ₅₀ of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time:	24 hours
Result:	Inhibited NF-κB activities in HepG2 cells.

Western Blot Analysis

Cell Line:	HepG2 cells
Concentration:	0 μM, 1 μM, 2 μM, 4 μM
Incubation Time:	30 minutes
Result:	Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.