ChemicalBook CAS数据库列表 A 77-01
A 77-01
- CAS号:607737-87-1
- 英文名:4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
- 中文名:A 77-01
- CBNumber:CB6727914
- 分子式:C18H14N4
- 分子量:286.33
- MOL File:607737-87-1.mol
A 77-01化学性质
- 储存条件 :Store at -20°C
- 溶解度 :insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
- 形态 :solid
- 颜色 :Off-white to light yellow
A 77-01性质、用途与生产工艺
- 生物活性 A 77-01 是一种有效的 TGF-β I 型受体家族 ALK5 抑制剂，IC50 值为 25 nM。
-
靶点
IC50: 25 nM (ALK5)
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体外研究
A-77-01 (0.01-10 µM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.
A-77-01 (1 µM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.
A-77-01 (1 µM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.RT-PCR
Cell Line: Mv1Lu cells Concentration: 0.01 µM, 0.03 µM, 0.1 µM, 0.3 µM, 1 µM, 3 µM, 10 µM Incubation Time: 25 hours Result: Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion. Cell Viability Assay
Cell Line: Mv1Lu cells Concentration: 1 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Efficiently prevented the growth-inhibitory effects of TGF-β. Western Blot Analysis
Cell Line: HaCaT cells Concentration: 1 µM Incubation Time: 30 minutes Result: Inhibited TGF-β-induced phosphorylation of Smad2.
A 77-01上下游产品信息
上游原料
下游产品
A 77-01 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-78349
- 产品名称：A 77-01 A 77-01
- CAS编号：607737-87-1
- 包装：5mg
- 价格：988元
- 更新日期：2024/11/08
- 产品编号：HY-78349
- 产品名称：A 77-01 A 77-01
- CAS编号：607737-87-1
- 包装：10mM * 1mLin DMSO
- 价格：1086元
A 77-01生产厂家
- 公司名称：Axon Medchem BV
- 联系电话：--
- 电子邮件：info@axonmedchem.com
- 国家：荷兰
- 产品数：477
- 优势度：30
