ChemicalBook CAS数据库列表 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
- CAS号:170846-89-6
- 英文名:E4CPG
- 中文名:4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
- CBNumber:CB6692522
- 分子式:C11H13NO4
- 分子量:223.23
- MOL File:Mol file
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID化学性质
- 沸点 :431.3±40.0 °C(Predicted)
- 密度 :1.337±0.06 g/cm3(Predicted)
- 储存条件 :Store at RT
- 溶解度 :H2O : < 0.1 mg/mL (insoluble)DMSO : < 1 mg/mL (insoluble or slightly soluble)
- 形态 :Powder
- 酸度系数(pKa) :1.76±0.10(Predicted)
- 颜色 :White to off-white
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID性质、用途与生产工艺
- 生物活性 E4CPG ((RS)-ECPG) 是一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。
-
靶点
mGluR
-
体外研究
E4CPG acts at rat cortical mGluR with the K B value of 0.367 mM.
-
体内研究
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) .
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.Animal Model: Male Swiss mice (25-35 g) Dosage: 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.) Administration: Single injection Result: The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). Animal Model: Male Sprague-Dawley rats Dosage: 35 nM/3.5 μL Administration: Single injection, i.c.v. Result: Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID上下游产品信息
上游原料
下游产品
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-100372
- 产品名称：4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG
- CAS编号：170846-89-6
- 包装：5mg
- 价格：600元
- 更新日期：2024/11/08
- 产品编号：HY-100372
- 产品名称：4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG
- CAS编号：170846-89-6
- 包装：10mg
- 价格：800元
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
