8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
- CAS号:51116-01-9
- 英文名:8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- 中文名:8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
- CBNumber:CB6687726
- 分子式:C10H12BrN5NaO7P
- 分子量:448.1
- MOL File:51116-01-9.mol
- 储存条件 :-20°C
- 溶解度 :H2O: 100 mg/mL
- 形态 :powder
- 颜色 :White to off-white
- 水溶解性 :Soluble to 100 mM in water
- WGK Germany :3
- F :10-21
- 海关编码 :29349990
8-溴代鸟苷-3',5'-环状单磷酸酯钠盐性质、用途与生产工艺
- 生物活性 8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物，是一种 PKG 激活剂。8-Bromo-cGMP sodium 可显着抑制 Ca2+ 宏观电流并损害高 K+ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有镇痛和血管舒张作用。
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靶点
Ca 2+
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体外研究
8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently.
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.
Cell Viability Assay
Cell Line: LLC-PK1 cells (ATCC CL 101) Concentration: 1-100 μM Incubation Time: 8 hours Result: Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%. Western Blot Analysis
Cell Line: LLC-PK1 cells (ATCC CL 101) Concentration: 1-100 μM Incubation Time: 16 hours Result: Induced the synthesis of HO-1 protein in a concentration-dependent fashion. -
体内研究
8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).
- 更新日期：2024/11/08
- 产品编号：HY-101379A
- 产品名称：8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 8-Bromo-cGMP sodium
- CAS编号：51116-01-9
- 包装：5mg
- 价格：700元
- 更新日期：2024/11/08
- 产品编号：HY-101379A
- 产品名称：8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 8-Bromo-cGMP sodium
- CAS编号：51116-01-9
- 包装：10mM * 1mLin Water
- 价格：770元
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