RADIOPROTECTIN-1
- CAS号:1622006-09-0
- 英文名:Radioprotectin-1
- 中文名:RADIOPROTECTIN-1
- CBNumber:CB65419827
- 分子式:C23H19ClN2O6S
- 分子量:486.92
- MOL File:1622006-09-0.mol
- 沸点 :720.6±70.0 °C(Predicted)
- 密度 :1.490±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : 125 mg/mL (256.72 mM);Water : < 0.1 mg/mL (insoluble)
- 酸度系数(pKa) :2.69±0.36(Predicted)
- 形态 :Solid
- 颜色 :White to light yellow
RADIOPROTECTIN-1性质、用途与生产工艺
- 生物活性 Radioprotectin-1 是一种高效特异性的溶血磷脂酸受体 2 (LPA2) 激动剂,EC50 值为 25 nM (鼠源 LPA2 亚型) 。
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靶点
EC50: 25 nM (murine LPA 2 subtype)
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体外研究
Radioprotectin-1 is a potent agonist of LPA 2 with an EC 50 of 5 pM and functions as a full agonist at the human ortholog of LPA 2 .
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA 2 either endogenously or after transfection.
Cell Viability Assay
Cell Line: MEF cells , IEC-6 cells Concentration: 0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM Incubation Time: 15 minutes Result: Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic Adiamycin. -
体内研究
Radioprotectin-1 is a high-potency specific agonist of the murine LPA 2 GPCR .
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA 2 GPCR in Lgr5 + stem cells.
Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) Dosage: 0.1 mg/kg, 0.3 mg/kg Administration: Subcutaneous injection; every 12 hours; for 3 days Result: Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
- 更新日期:2024/08/19
- 产品编号:HY-114380
- 产品名称:Radioprotectin-1
- CAS编号:
- 包装:1 mg
- 价格:1480元
- 更新日期:2024/08/19
- 产品编号:HY-114380
- 产品名称:RADIOPROTECTIN-1 Radioprotectin-1
- CAS编号:1622006-09-0
- 包装:5mg
- 价格:3700元
- 公司名称:TargetMol Chemicals Inc.
- 联系电话:+1-781-999-5354 +1-00000000000
- 电子邮件:marketing@targetmol.com
- 国家:美国
- 产品数:19892
- 优势度:58
- 公司名称:MedChemExpress
- 联系电话:--
- 电子邮件:sales@medchemexpress.com
- 国家:美国
- 产品数:6398
- 优势度:58