NL-1
- CAS号:188532-26-5
- 英文名:NL 1
- 中文名:NL-1
- CBNumber:CB65417106
- 分子式:C18H25NO3S
- 分子量:335.46
- MOL File:188532-26-5.mol
- 沸点 :446.5±40.0 °C(Predicted)
- 密度 :1.167±0.06 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Store in freezer, under -20°C
- 溶解度 :DMSO: 250 mg/mL (745.25 mM)
- 酸度系数(pKa) :6.34±0.50(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
NL-1性质、用途与生产工艺
- 生物活性 NL-1 是一种具有抗白血病作用的 mitoNEET 抑制剂。NL-1 抑制 REH 和 REH/Ara-C 细胞生长，IC50 分别为 47.35 µM 和 56.26 µM。NL-1 介导的白血病细胞死亡需要激活自噬途径。
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靶点
MitoNEET
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体外研究
NL-1 (10-100 μM; 72 hours; REH, REH/Ara-C and ALL cell lines) treatment reduces the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner. NL-1 inhibits SUPB15, NALM6 with IC 50 s of 29.48 µM, 94.26 µM, respectively. TOM1, BV173, NALM1 and JM1 all have similar IC 50 values of around 60 µM for NL-1.
NL-1 (60 μM; 6 hours; REH, REH/Ara-C cell lines) treatment mediates autophagy, and inhibition of autophagy partially decreased NL-1-induced tumor cell death.
NL-1 pretreatment inhibits the chemotactic ability of both REH and REH/Ara-C cells to migrate towards multiple chemoattractants. The cells treated with NL1 shows a dose-dependent decrease in chemotaxis both in the REH and the REH/AraC cells.Cell Proliferation Assay
Cell Line: REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM Incubation Time: 72 hours Result: Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner. Cell Autophagy Assay
Cell Line: REH, REH/Ara-C cell lines Concentration: 60 μM Incubation Time: 6 hours Result: Induced cell autophagy. -
体内研究
NL-1 (10 mg/kg; intraperitoneal injection; daily; for 5 days; female NSG mice) treatment shows antileukemic activity in an in vivo mouse ALL model.
Animal Model: 10 female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells Dosage: 10 mg/kg Administration: Intraperitoneal injection; daily; for 5 days Result: Showed antileukemic activity in an in vivo mouse ALL model.
- 更新日期：2024/11/08
- 产品编号：HY-135231
- 产品名称：NL-1
- CAS编号：
- 包装：5 mg
- 价格：435元
- 更新日期：2024/11/08
- 产品编号：HY-135231
- 产品名称：NL-1 NL-1
- CAS编号：188532-26-5
- 包装：10mM * 1mLin DMSO
- 价格：506元
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32161
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：57505
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：
- 电子邮件：support@targetmol.com
- 国家：美国
- 产品数：38631
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
