S-腺苷甲硫氨酸对甲苯磺酸盐

生物活性体外研究体内研究 S-腺苷甲硫氨酸对甲苯磺酸盐试剂级价格

S-腺苷甲硫氨酸对甲苯磺酸盐

CAS号:71914-80-2
英文名:S-Adenosyl-L-methionine tosylate
中文名:S-腺苷甲硫氨酸对甲苯磺酸盐
CBNumber:CB6482930
分子式:C15H23N6O5S.C7H7O3S
分子量:570.64
MOL File:71914-80-2.mol

S-腺苷甲硫氨酸对甲苯磺酸盐化学性质

储存条件 :−20°C
溶解度 :H₂O: 0.1 g/mL, clear

安全信息

WGK Germany :3
F :1-10

S-腺苷甲硫氨酸对甲苯磺酸盐性质、用途与生产工艺

生物活性 S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine tosylate 是一种具有有效的抗抑郁和镇痛作用的膳食补充剂，并可用于肝病和骨关节炎的研究。
体外研究

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine.
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits.
体内研究

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC.