S-腺苷甲硫氨酸对甲苯磺酸盐
- CAS号:71914-80-2
- 英文名:S-Adenosyl-L-methionine tosylate
- 中文名:S-腺苷甲硫氨酸对甲苯磺酸盐
- CBNumber:CB6482930
- 分子式:C15H23N6O5S.C7H7O3S
- 分子量:570.64
- MOL File:71914-80-2.mol
- 储存条件 :−20°C
- 溶解度 :H2O: 0.1 g/mL, clear
- WGK Germany :3
- F :1-10
S-腺苷甲硫氨酸对甲苯磺酸盐性质、用途与生产工艺
- 生物活性 S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine tosylate 是一种具有有效的抗抑郁和镇痛作用的膳食补充剂,并可用于肝病和骨关节炎的研究。
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体外研究
S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine.
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits. -
体内研究
Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC.
- 更新日期:2024/11/08
- 产品编号:HY-B0617A
- 产品名称:S-腺苷甲硫氨酸对甲苯磺酸盐 S-Adenosyl-L-methionine tosylate
- CAS编号:71914-80-2
- 包装:50mg
- 价格:750元
- 更新日期:2024/11/08
- 产品编号:HY-B0617A
- 产品名称:S-腺苷甲硫氨酸对甲苯磺酸盐 S-Adenosyl-L-methionine tosylate
- CAS编号:71914-80-2
- 包装:10mM * 1mLin Water
- 价格:825元
- 公司名称:Service Chemical Inc.
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- 国家:德国
- 产品数:6350
- 优势度:71