BETA-AMYLOID (1-28)
- CAS号:109770-29-8
- 英文名:H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
- 中文名:BETA-AMYLOID (1-28)
- CBNumber:CB6344029
- 分子式:C145H209N41O46
- 分子量:3262.46
- MOL File:109770-29-8.mol
- 密度 :1.52±0.1 g/cm3(Predicted)
- 储存条件 :−20°C
- 溶解度 :Soluble in DMSO
- 形态 :White lyophilized powder.
- 序列 :H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
- WGK Germany :3
BETA-AMYLOID (1-28)性质、用途与生产工艺
- 生物活性 β-Amyloid (1-28) 是可参与金属结合的β-淀粉样蛋白片段。β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。
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靶点
Amyloid-β
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体外研究
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. -
体内研究
β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu 2+ interaction. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K a 10 7 M -1 .
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参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%
- 更新日期:2023/03/20
- 产品编号:HY-P1468
- 产品名称:BETA-AMYLOID (1-28) β-Amyloid (1-28)
- CAS编号:109770-29-8
- 包装:1mg
- 价格:1600元
- 更新日期:2023/03/20
- 产品编号:HY-P1468
- 产品名称:BETA-AMYLOID (1-28) β-Amyloid (1-28)
- CAS编号:109770-29-8
- 包装:5mg
- 价格:6400元
- 公司名称:Carbosynth
- 联系电话:--
- 电子邮件:sales@carbosynth.com
- 国家:英国
- 产品数:6005
- 优势度:58
- 大豆肽 β-淀粉样蛋白(1-42),鼠 β淀粉样蛋白 (1-15) 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸 淀粉Β-蛋白(22-35) 淀粉Β-蛋白 Amyloid β-Protein (1-12) BETA-淀粉样肽(1-40) BETA- AMYLOID (1-16) Amyloid β-Protein (3-40) Amyloid Beta-Protein (1-14) BETA-淀粉样蛋白片断25-35 Amyloid β-Protein (4-42) ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY 淀粉Β-蛋白(1-43) Amyloid β-Protein (1-6) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA-THR-VAL-ILE-VAL-OH