ChemicalBook CAS数据库列表 CS-2826
CS-2826
- CAS号:1802637-39-3
- 英文名:BB-Cl-Amidine
- 中文名:CS-2826
- CBNumber:CB63152560
- 分子式:C26H26ClN5O
- 分子量:459.971
- MOL File:1802637-39-3.mol
CS-2826化学性质
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM)
Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) - 形态 :A crystalline solid
CS-2826性质、用途与生产工艺
- 生物活性 BB-Cl-Amidine 是肽基精氨酸脱胺酶 (PAD) 的抑制剂。
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靶点
PAD.
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体内研究
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely.
Animal Model: MRL/lpr mice. Dosage: 1 mg/kg. Administration: Subcutaneous injection daily from 8 to 14 weeks of age. Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
CS-2826上下游产品信息
上游原料
下游产品
CS-2826生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
