生物活性 体外研究 BRD7552 试剂级价格
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BRD7552

BRD7552,1137359-47-7,结构式
BRD7552
  • CAS号:1137359-47-7
  • 英文名:ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate
  • 中文名:BRD7552
  • CBNumber:CB62744621
  • 分子式:C33H33N3O15
  • 分子量:711.63
  • MOL File:1137359-47-7.mol
BRD7552化学性质
  • 沸点 :757.6±60.0 °C(Predicted)
  • 密度 :1.53±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
  • 形态 :A crystalline solid
  • 酸度系数(pKa) :11.81±0.20(Predicted)
  • 颜色 :White to off-white

BRD7552性质、用途与生产工艺

  • 生物活性 BRD7552 是一种 PDX1 转录因子诱导剂,它上调了人类原代胰岛和导管细胞中 PDX1 的表达,并诱导 PDX1 启动子的表观遗传变化与转录激活一致。BRD7552 增加胰岛素表达。PDX1 是参与胰腺发育和β细胞功能的关键转录因子。
  • 体外研究

    BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells.
    BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner.

    Western Blot Analysis

    Cell Line: PANC-1 cells
    Concentration: 1.25, 2.5, 5 μM
    Incubation Time: 5 days
    Result: Induced a dose-dependent increase in PDX1 protein levels.
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BRD7552 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-19694
  • 产品名称:BRD7552
  • CAS编号:
  • 包装:1 mg
  • 价格:365元
  • 更新日期:2024/11/08
  • 产品编号:HY-19694
  • 产品名称:BRD7552 BRD7552
  • CAS编号:1137359-47-7
  • 包装:5mg
  • 价格:880元
BRD7552生产厂家
  • 公司名称:MedChemexpress LLC
  • 联系电话:021-58955995
  • 电子邮件:sales@medchemexpress.cn
  • 国家:美国
  • 产品数:4861
  • 优势度:58