ChemicalBook CAS数据库列表 5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
![5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮,183204-74-2,结构式](https://www.chemicalbook.com/CAS/20180703/GIF/183204-74-2.gif)
- CAS号:183204-74-2
- 英文名:5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
- 中文名:5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
- CBNumber:CB62744247
- 分子式:C9H11ClN4O2
- 分子量:242.66
- MOL File:183204-74-2.mol
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮化学性质
- 密度 :1.71±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Water: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
- 酸度系数(pKa) :7.06±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to off-white
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮性质、用途与生产工艺
- 生物活性 Tipiracil 是一种胸苷磷酸化酶 (TPase) 抑制剂。
-
靶点
thymidine phosphorylase
-
体外研究
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor.
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮上下游产品信息
上游原料
下游产品
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮生产厂家
- 公司名称：CLEARSYNTH LABS LTD.
- 联系电话：--
- 电子邮件：sales@clearsynth.com
- 国家：印度
- 产品数：6257
- 优势度：58
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