8-(2-羟基苯甲酰胺基)辛酸钠

简介生物活性体外研究体内研究 8-(2-羟基苯甲酰胺基)辛酸钠试剂级价格

8-(2-羟基苯甲酰胺基)辛酸钠

CAS号:203787-91-1
英文名:Salcaprozate Sodium
中文名:8-(2-羟基苯甲酰胺基)辛酸钠
CBNumber:CB62739113
分子式:C15H22NNaO4
分子量:303.33
MOL File:203787-91-1.mol

8-(2-羟基苯甲酰胺基)辛酸钠化学性质

熔点 :183 - 185°C
储存条件 :Inert atmosphere,Room Temperature
溶解度 :DMSO (Slightly), Methanol (Slightly)
形态 :Solid
颜色 :White to Off-White
稳定性 :Hygroscopic
InChI :InChI=1S/C15H21NO4.Na.H/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);;
InChIKey :OBKUJEVXEMKQMJ-UHFFFAOYSA-N
SMILES :C(C1C=CC=CC=1O)(=O)NCCCCCCCC(=O)O.[NaH]

8-(2-羟基苯甲酰胺基)辛酸钠性质、用途与生产工艺

简介
8-(2-羟基苯甲酰胺基)辛酸钠，简称SNAC，是一种二碳磷酸盐化合物吸收促进剂，用于治疗胃肠道疾病，尤其适用于二碳磷酸盐化合物吸收不良引起的肠胃道疾病。
生物活性 Salcaprozate sodium (SNAC) 是一种口服吸收促进剂，有潜力作为口服形式的肝素和胰岛素的递送剂。Salcaprozate sodium 可增加非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。
体外研究

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.

体内研究

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d.

Animal Model:	Sprague-Dawley rats (6-7 weeks)
Dosage:	2000 mg/kg/d
Administration:	Oral gavage for 13 weeks
Result:	Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.