CAY10574
- CAS号:140651-18-9
- 英文名:CAY10574
- 中文名:CAY10574
- CBNumber:CB62590428
- 分子式:C9H10N6O
- 分子量:218.22
- MOL File:140651-18-9.mol
- 沸点 :638.3±55.0 °C(Predicted)
- 密度 :1.67±0.1 g/cm3(Predicted)
- 储存条件 :+2C to +8C
- 溶解度 :DMF: 0.5 mg/ml; DMSO: 0.5 mg/ml
- 酸度系数(pKa) :8.52±0.30(Predicted)
- 形态 :Yellow semi-solid
- 颜色 :Light yellow to yellow
CAY10574性质、用途与生产工艺
- 生物活性 CAN508 是一种有效的、ATP 竞争性抑制 CDK9/cyclin T1，IC50为 0.35 μM。CAN508 对 CDK9/cyclin T1 比对其他的 CDK/cyclin 高出 38 倍的选择性。CAN508 具有抗肿瘤活性。
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靶点
CDK9/cyclinT1
0.35 μM (IC 50 )
CDK2/cyclinE
20 μM (IC 50 )
cdk2/cyclin A
69 μM (IC 50 )
Cdk4/cyclin D1
13.5 μM (IC 50 )
CDK7/cyclin H
26 μM (IC 50 )
Cdk1/cyclin B
44 μM (IC 50 )
-
体外研究
CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays.
CAN508 (20-40 μM; 72 hours) significantly reduces cell proliferation in a dose dependent manner in all three esophageal adenocarcinoma cell lines (SKGT4, OE33 and FLO-1 cells) with IC 50 s ranging from 34.99 to 91.09 μM.
CAN508 (40 μM; 72 hours) increases apoptosis in all three esophageal adenocarcinoma cells.Apoptosis Analysis
Cell Line: SKGT4, OE33 and FLO-1 cells Concentration: 40 μM Incubation Time: 72 hours Result: Increased apoptosis by 2 fold in all three esophageal adenocarcinoma cells compared to untreated controls. -
体内研究
CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts.
Animal Model: 4 weeks-old female nude mice (esophageal adenocarcinoma xenografts) Dosage: 60 mg/kg Administration: I.p.; daily for 10 days Result: Caused reduction of tumor growth starting from post-treatment day three with 50.83% reduction.
- 更新日期：2024/11/08
- 产品编号：HY-100429
- 产品名称：CAN508
- CAS编号：
- 包装：1 mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-100429
- 产品名称：CAY10574 CAN508
- CAS编号：140651-18-9
- 包装：5mg
- 价格：600元
- 公司名称：OTAVA-BB
- 联系电话：--
- 电子邮件：north.america@otavachemicals.com
- 国家：乌克兰
- 产品数：6495
- 优势度：72
