ChemicalBook CAS数据库列表 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑
![3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑,271576-80-8,结构式](https://www.chemicalbook.com/CAS/20180713/GIF/271576-80-8.gif)
- CAS号:271576-80-8
- 英文名:3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
- 中文名:3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑
- CBNumber:CB62554318
- 分子式:C20H20ClN5O2
- 分子量:397.86
- MOL File:271576-80-8.mol
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑化学性质
- 沸点 :652.6±55.0 °C(Predicted)
- 密度 :1.367
- 储存条件 :2-8°C
- 溶解度 :DMSO : 50 mg/mL (125.67 mM; Need ultrasonic)
- 形态 :Powder
- 酸度系数(pKa) :9.39±0.50(Predicted)
- 颜色 :White to off-white
安全信息
- 海关编码 :2924297099
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑性质、用途与生产工艺
- 生物活性 SD 0006 (SD-06) 是口服有效的、选择性的、ATP竞争性的、有效的 p38α MAPK 的二芳基吡唑抑制剂，其IC50 值为 110 nM。
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靶点
IC50: 110 nM (p38 MAPK).
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体外研究
SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate.
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体内研究
SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy.
SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling.Animal Model: 8- to 12-week-old DBA/1 mice. Dosage: 3.75, 7.5 and 15 mg/kg. Administration: Orally twice daily. Result: Inhibited the transcription of several inflammatory mediators to prevent joint swelling and bone destruction and to preserve bone density.
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑上下游产品信息
上游原料
下游产品
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-11087
- 产品名称：SD 0006
- CAS编号：
- 包装：1 mg
- 价格：500元
- 更新日期：2024/11/08
- 产品编号：HY-11087
- 产品名称：3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑 SD 0006
- CAS编号：271576-80-8
- 包装：5mg
- 价格：1100元
3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑生产厂家
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
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