HA 130,自分泌运动抑制剂

HA 130,自分泌运动抑制剂化学性质

储存条件 :Store at -20°C
溶解度 :DMF:10.0(Max Conc. mg/mL);21.58(Max Conc. mM)
DMSO:30.11(Max Conc. mg/mL);64.99(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
形态 :Powder
颜色 :Light yellow to yellow

HA 130,自分泌运动抑制剂性质、用途与生产工艺

用途
HA 130,自分泌运动抑制剂是一种选择性的 autotaxin (ATX) 抑制剂，IC50 为 28 nM。
靶点

Autotaxin

28 nM (IC ₅₀ )
体外研究

HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.
体内研究

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle.
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).

HA 130,自分泌运动抑制剂上下游产品信息

上游原料

下游产品

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