生物活性 靶点 体外研究 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol 试剂级价格
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ChemicalBook  CAS数据库列表  1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol

1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol

生物活性 靶点 体外研究 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol 试剂级价格
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol,1125593-20-5,结构式
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
  • CAS号:1125593-20-5
  • 英文名:1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
  • 中文名:1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
  • CBNumber:CB62524940
  • 分子式:C28H33N5O4S
  • 分子量:535.66
  • MOL File:1125593-20-5.mol
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol化学性质
  • 密度 :1.354±0.06 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :insoluble in H2O; ≥16.05 mg/mL in DMSO; ≥9.26 mg/mL in EtOH
  • 形态 :solid
  • 酸度系数(pKa) :14.76±0.20(Predicted)
  • 颜色 :Light yellow to yellow

1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol性质、用途与生产工艺

  • 生物活性 Mps1-IN-1 是一种有效的，选择性的，ATP 竞争性的 Mps1 抑制剂，IC50 和 Kd 值分别为 367 nM 和 27 nM。
  • 靶点

    Mps1

    367 nM (IC 50 )

    Mps1

    27 nM (Kd)

    ALK

    21 nM (Kd)

    LTK

    29 nM (Kd)

    PYK2

    280 nM (Kd)

    FAK

    440 nM (Kd)

    IGF1R

    750 nM (Kd)

    INSR

    470 nM (Kd)

    CLK1

    1900 nM (Kd)

    ERK2

    2900 nM (Kd)

    INSRR

    1200 nM (Kd)

    TNK1

    2600 nM (Kd)

    TNK2

    3100 nM (Kd)

    GAK

    1100 nM (Kd)

  • 体外研究

    Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 367 nM and 27 nM. Mps1-IN-1 also has high affinity for ALK, and LTK, with K d s of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 (5-10 µM) suppresses the proliferative capacity of HCT116.

1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol上下游产品信息
上游原料
下游产品
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-13298
  • 产品名称：Mps1-IN-1
  • CAS编号：
  • 包装：1 mg
  • 价格：386元
  • 更新日期：2024/11/08
  • 产品编号：HY-13298
  • 产品名称：1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol Mps1-IN-1
  • CAS编号：1125593-20-5
  • 包装：5mg
  • 价格：850元
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