ChemicalBook CAS数据库列表 TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
- CAS号:200189-97-5
- 英文名:N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
- 中文名:TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
- CBNumber:CB62518844
- 分子式:C23H21NO5
- 分子量:391.42
- MOL File:200189-97-5.mol
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346化学性质
- 储存条件 :Store at +4°C
- 溶解度 :Soluble in DMSO
- 形态 :solid
- 颜色 :White
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346性质、用途与生产工艺
- 生物活性 Omigapil maleate 是一种具有口服活性的 GAPDH 亚硝基化抑制剂，可消除 Aβ1-42 诱导的小鼠 tau 乙酰化，记忆障碍和运动功能障碍，Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。
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靶点
Apoptosis
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体内研究
Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force.
Animal Model: 12-week-old dyW/ mag mice Dosage: 0.1 mg/kg Administration: For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage.Result: Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil.
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346上下游产品信息
上游原料
下游产品
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346生产厂家
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
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