ChemicalBook CAS数据库列表 Unii-7D0yb67S97
Unii-7D0yb67S97
- CAS号:332348-12-6
- 英文名:Unii-7D0yb67S97
- 中文名:Unii-7D0yb67S97
- CBNumber:CB62496133
- 分子式:
- 分子量:0
- MOL File:Mol file
Unii-7D0yb67S97化学性质
- 储存条件 :Store at 4°C, do not freeze
- 形态 :Liquid
- 颜色 :Colorless to light yellow
- 水溶解性 :Soluble in water
Unii-7D0yb67S97性质、用途与生产工艺
- 生物活性 Abatacept (CTLA4lg) 是一种可溶性融合蛋白，由人 CTLA4 的胞外结构域和人 IgG1 Fc 部分的片段 (铰链，CH2 和 3 结构域) 组成。Abatacept 是选择性 T 细胞共刺激调节剂，也是一种用于自身免疫性疾病的蛋白药物。
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体内研究
Abatacept reduces paw edema, and the SC Multiple-dose group shows significantly greater (t obs = 2.50) paw edema reduction compared with the IV dose group.
Abatacept exhibits linear PK across the studied doses. The NCA clearance (CL) is 20.8 mL/day/kg, volume (V ss ) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%.
Abatacept (oral; 10 mg/kg; every 2 days) reduces the proportion of activated T cells (CD44highCD62L–) and inhibits the up-regulation of ICOS and CD71 in homozygous DO11.10 RAG-2 –/– BALB/c (H-2d/d) mice.
Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g Dosage: 10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29 Administration: IV or SC Result: Reduced paw edema, and the SC Multiple-dose group showed significantly greater (t obs = 2.50) paw edema reduction compared with the IV dose group. Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g Dosage: 10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29 (Pharmacokinetic Study) Administration: IV or SC Result: The NCA clearance (CL) is 20.8 mL/day/kg, volume (V ss ) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%.
Unii-7D0yb67S97上下游产品信息
上游原料
下游产品
Unii-7D0yb67S97 试剂级价格
- 更新日期：2024/08/19
- 产品编号：HY-108829
- 产品名称：Unii-7D0yb67S97 Abatacept
- CAS编号：332348-12-6
- 包装：1mg
- 价格：4000元
- 更新日期：2024/08/19
- 产品编号：HY-108829
- 产品名称：Unii-7D0yb67S97 Abatacept
- CAS编号：332348-12-6
- 包装：5mg
- 价格：8200元
Unii-7D0yb67S97生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32024
- 优势度：58
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52925
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
