多西苯醌
- CAS号:80809-81-0
- 英文名:AA-861
- 中文名:多西苯醌
- CBNumber:CB6246024
- 分子式:C21H26O3
- 分子量:326.43
- MOL File:80809-81-0.mol
- 储存条件 :2-8°C
- 溶解度 :ethanol:
- 形态 :A solid
- 颜色 :Light yellow to yellow
多西苯醌性质、用途与生产工艺
- 生物活性 Docebenone (AA 861) 是一种有效的、选择性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制剂。
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靶点
5-LO
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体外研究
Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB 4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca 2+ ] i concentration dependently.
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体内研究
Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10 -8 -10 -5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10 -8 -10 -5 M.
- 更新日期：2024/11/08
- 产品编号：HY-12886
- 产品名称：Docebenone
- CAS编号：
- 包装：1 mg
- 价格：1600元
- 更新日期：2024/11/08
- 产品编号：HY-12886
- 产品名称：多西苯醌 Docebenone
- CAS编号：80809-81-0
- 包装：5mg
- 价格：4000元
- 公司名称：Carbone Scientific CO., LTD
- 联系电话：--
- 电子邮件：sales@carbonesci.com
- 国家：英国
- 产品数：6666
- 优势度：30
- 公司名称：UK GREEN SCIENTIFIC CO.,LIMITED
- 联系电话：--
- 电子邮件：sales@gs-chem.com
- 国家：英国
- 产品数：6098
- 优势度：47
