ChemicalBook CAS数据库列表 STO-609
STO-609
- CAS号:52029-86-4
- 英文名:7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- 中文名:STO-609
- CBNumber:CB6245603
- 分子式:C19H10N2O3
- 分子量:314.29
- MOL File:52029-86-4.mol
STO-609化学性质
- 熔点 :>300 °C
- 沸点 :716.9±62.0 °C(Predicted)
- 密度 :1.54±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :DMSO: 15 mg/mL at ≥60 °C
- 形态 :solid
- 酸度系数(pKa) :2.65±0.20(Predicted)
- 颜色 :Light yellow to yellow
安全信息
- 安全说明 :22-24/25
- WGK Germany :3
STO-609性质、用途与生产工艺
- 生物活性 STO-609 是特异性的CaM-KK的抑制剂,抑制CaM-KKα和CaM-KKβ的活性,Ki值分别为80 ng/ml和15 ng/ml,并抑制其自身磷酸化活性。STO-609 可抑制 AMPKK 活性并抑制自噬。
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靶点
Target Value AMPK
()CaM-KKβ
(Cell-free assay)47 nM(Ki) CaM-KKα
(Cell-free assay)0.25 μM(Ki) -
体外研究
STO-609抑制重组CaM-KKα和CaM-KKβ的活性,Ki值分别为80 ng/ml和15 ng/ml,STO-609还抑制它们的自身磷酸化活性。STO-609对CaM-KK具有高度选择性,对其下游 CaM激酶(CaM-KI and -IV)没有显著作用。在转染的Hela细胞中,STO-609以剂量依赖方式抑制Ca。
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体内研究
对成年小鼠体内给药,STO-609会引起造骨细胞的增多、破骨细胞的减少,对卵巢切除术引发的骨质疏松症具有保护作用。脑室注射STO-609不影响对神经低血糖症的负调节反应、对低血糖引起的AMPK激活也没有影响。
- 用途 一种特异性的CaM-KK的抑制剂,抑制CaM-KKα和CaM-KKβ,Ki值分别为80ng/ml和15ng/ml,并抑制其自身磷酸化活性。STO-609 is a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC(50) value of the compound against CaM-KII is approximately 10 microg/ml. STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro.
STO-609上下游产品信息
上游原料
下游产品
STO-609 试剂级价格
- 更新日期:2024/11/08
- 产品编号:HY-19805
- 产品名称:STO-609 STO-609
- CAS编号:52029-86-4
- 包装:1mg
- 价格:400元
- 更新日期:2024/11/08
- 产品编号:HY-19805
- 产品名称:STO-609 STO-609
- CAS编号:52029-86-4
- 包装:5mg
- 价格:800元
STO-609生产厂家
- 公司名称:TOCRIS-US
- 联系电话:--
- 电子邮件:customerservice@tocris.co.uk
- 国家:英国
- 产品数:5726
- 优势度:77
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