1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
![1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile,150651-39-1,结构式](https://www.chemicalbook.com/CAS/20180711/GIF/150651-39-1.gif)
- CAS号:150651-39-1
- 英文名:1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
- 中文名:1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
- CBNumber:CB62064356
- 分子式:C20H13N5
- 分子量:323.35
- MOL File:150651-39-1.mol
- 密度 :1.31±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO:30.0(Max Conc. mg/mL);92.78(Max Conc. mM)
- 形态 :A crystalline solid
- 酸度系数(pKa) :2.90±0.50(Predicted)
- 颜色 :Light yellow to yellow
1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile性质、用途与生产工艺
- 生物活性 iFSP1 是一种有效的、选择性的且不依赖谷胱甘肽的 ferroptosis suppressor protein 1 (FSP1/AIFM2) 的抑制剂，EC50值为103 nM。iFSP1 可在过表达FSP1的GPX4基因敲除的Pfa1细胞和HT1080细胞中选择性诱导铁死亡。
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靶点
Target Value FSP1/AIFM2
(Cell-free assay)103 nM(EC50) -
体外研究
iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1)
Cell Proliferation Assay
Cell Line: Wild-type and Gpx4-knockout Pfa1 or HT 1080 cells overexpressing FSP1–HA Concentration: 0.001-1 μM Incubation Time: 24 hours Result: Was toxic to cells that depend solely (no GPX4 expression detectable) on FSP1 function. Cell Viability Assay
Cell Line: NCl-H1437, NCl-H1437 FSP1 KO, U-373, U-373 FSP1 KO, MDA-MB-436, MDA-MB-436 FSP1 KO, SW620, SW620 FSP1 KO, MDA-MB-435S, MDA-MB-435S FSP1 KO, A549 and A549 FSP1 KO Concentration: 3 μM Incubation Time: 24 hours Result: Sensitized a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3.
- 更新日期：2024/11/08
- 产品编号：HY-136057
- 产品名称：iFSP1
- CAS编号：
- 包装：5 mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-136057
- 产品名称：1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile iFSP1
- CAS编号：150651-39-1
- 包装：10mg
- 价格：480元
- 公司名称：TargetMol Chemicals Inc.
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