奥替那班
- CAS号:686344-29-6
- 英文名:Otenabant
- 中文名:奥替那班
- CBNumber:CB61518526
- 分子式:C25H25Cl2N7O
- 分子量:510.42
- MOL File:686344-29-6.mol
- 沸点 :757.9±70.0 °C(Predicted)
- 密度 :1.46
- 储存条件 :Store at -20°C
- 溶解度 :DMSO : 100 mg/mL (195.92 mM; Need ultrasonic)
- 形态 :Powder
- 酸度系数(pKa) :16.30±0.20(Predicted)
- 颜色 :White to off-white
奥替那班性质、用途与生产工艺
- 生物活性 Otenabant 是一种有效的，选择性的 cannabinoid receptor CB1 拮抗剂，Ki 值为 0.7 nM，对其选择性是对 CB2 的 1000 多倍。
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靶点
Ki: 0.7 nM (CB1)
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体外研究
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration.
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体内研究
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
- 更新日期：2025/02/08
- 产品编号：HY-10871
- 产品名称：奥替那班 Otenabant
- CAS编号：686344-29-6
- 包装：5mg
- 价格：500元
- 更新日期：2025/02/08
- 产品编号：HY-10871
- 产品名称：奥替那班 Otenabant
- CAS编号：686344-29-6
- 包装：10mM * 1mLin DMSO
- 价格：561元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
