ChemicalBook CAS数据库列表 四碘甲状腺乙酸
四碘甲状腺乙酸
- CAS号:67-30-1
- 英文名:3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
- 中文名:四碘甲状腺乙酸
- CBNumber:CB6124010
- 分子式:C14H8I4O4
- 分子量:747.83
- MOL File:67-30-1.mol
四碘甲状腺乙酸化学性质
- 熔点 :219-220 °C (decomp)
- 沸点 :544.8±50.0 °C(Predicted)
- 密度 :2.727±0.06 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 溶解度 :acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow)
- 形态 :powder to crystal
- 酸度系数(pKa) :3.98±0.10(Predicted)
- 颜色 :White to Yellow to Green
- InChIKey :PPJYSSNKSXAVDB-UHFFFAOYSA-N
安全信息
四碘甲状腺乙酸性质、用途与生产工艺
- 生物活性 Tetrac (Tetraiodothyroacetic acid)，L-甲状腺素 (T4) 的天然衍生物，是甲状腺素整合素受体拮抗剂。Tetrac 阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3) 在整联蛋白 αvβ3 上甲状腺激素的细胞表面受体处的作用。Tetra 具有抗血管生成和抗肿瘤活性。
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体外研究
Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status.
Tetrac (0.1 μM; 30 min) inhibits activation of ERK1/2 in HT-29 and HCT116 cells.
Tetrac (0.1 μM; 24 h) inhibits expression of CCND1 and c-Myc , but promotes expression of CASP2 and THBS1 .Cell Proliferation Assay
Cell Line: HT-29 and HCT116 cells Concentration: 0.01, 0.1, 1 μM Incubation Time: 0, 2, 4, 6 days Result: Induced anti-proliferation of K-RAS wild-type colorectal cancer cells. Western Blot Analysis
Cell Line: HT-29 and HCT116 cells Concentration: 0.1 μM Incubation Time: 30 min Result: Inhibited constitutively activated ERK1/2, and this inhibition can remove by anti-integrin αvβ3 antibody pretreatment. -
体内研究
Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice.
Animal Model: Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells Dosage: 35 μg per day Administration: P.o. (added to the drinking water) daily for 40 days Result: Delayed the onset of ocular melanoma.
Reduced the S-100 and integrin staining level in the B16F10 mice model.
四碘甲状腺乙酸上下游产品信息
上游原料
下游产品
四碘甲状腺乙酸 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-W008859
- 产品名称：Tetrac
- CAS编号：
- 包装：5 mg
- 价格：312元
- 更新日期：2024/11/08
- 产品编号：HY-W008859
- 产品名称：四碘甲状腺乙酸 Tetrac
- CAS编号：67-30-1
- 包装：10mg
- 价格：500元
四碘甲状腺乙酸生产厂家
- 公司名称：Apin Chemicals Limited (UK)
- 联系电话：--
- 电子邮件：info@apinchemicals.com
- 国家：英国
- 产品数：6184
- 优势度：60
- 公司名称：APIN-NP
- 联系电话：--
- 电子邮件：info@apinchemicals.com
- 国家：英国
- 产品数：6807
- 优势度：42
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